Best CBD Oil For Anxiety & Depression 2021: Top 10 Brands

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Medically reviewed by Kimberly Langdon, MD

cbdfx tincture

CBDfx

  • Organic CBD
  • CO2 Extracted
  • Infused CBD oil tinctures
Spruce-Max-Potency-CBD-Oil

Spruce CBD

  • Full-spectrum CBD from high-quality hemp strains
  • Third-party tested
  • High potency
Joy organics

Joy Organics

  • THC-free available
  • High-quality hemp
  • CO2 extraction

An estimated 31.1%[1] of U.S. adults experience anxiety at some point in their lives. In fact, anxiety disorders[2] are the most prevalent type of mental disorder among adults in the United States. 

There are many different types of anxiety, ranging from generalized anxiety disorder (GAD), panic disorder, panic attacks, social anxiety disorder, post-traumatic stress disorder (PTSD), and more.  

Despite being highly treatable, only 36.9%[2] of those suffering from symptoms related to anxiety seek treatment. 

While it’s normal to occasionally feel anxious, if you have unwanted thoughts that never seem to fade, or you’re living in constant fear, it may be time to consider treatment.

Fortunately, there are many different treatment options for anxiety. One of the most popular natural treatments today for anxiety is cannabidiol (CBD).

This article will explore the relationship between CBD Oil and anxiety and discuss how to choose the best CBD for anxiety. You’ll also see our top ten picks.

Best CBD Oils on the market in (October. 2021)

  • CBDfx – Editor’s choice
  • Spruce CBD – Best for Anxiety
  • Joy Organics – Best Quality
  • Royal CBD – Best Variety
  • CBDPure – Best Budget Pick
  • CBDistillery – Best Certified
  • Nuleaf Naturals – Best Natural
  • Lazarus Naturals – Best Selection
  • American Shaman – Best Bioavailability
  • Charlotte’s Web – Best for Beginners

Does CBD Oil Help With Anxiety & Stress?

At this time, the Food and Drug Administration (FDA) has not approved CBD as a treatment for stress and anxiety. However, there is limited evidence that suggests CBD may help ease symptoms associated with anxiety.

A recent review of eight small studies[3] concluded that CBD could alleviate anxiety and anxiety-related symptoms. The review also concluded that CBD was generally well-tolerated, with the most common side effects being fatigue and sedation. 

Several other studies[4] have shown that CBD may alleviate symptoms associated with PTSD, such as inappropriate responses to traumatic memories.

The Line Up At A Glance

cbdfx tincture

Editor’s choice

CBDfx

  • Highly concentrated lab-grade CBD 
  • Full-spectrum CBD oil tinctures
  • Save 15% with recurring subscription

Spruce-Max-Potency-CBD-Oil

Best for Anxiety

Spruce CBD

  • Full-spectrum CBD from high-quality hemp strains
  • Third-party tested
  • High potency

Joy organics

Best Quality

Joy Organics

  • THC-free available
  • High-quality hemp
  • CO2 extraction

Royal CBD Oil

Best Variety

Royal CBD

  • Several concentrations offered
  • Full-spectrum CBD
  • C02 Extraction method

CBDPure-Oil

Best Budget Pick

CBDPure

  • Certified organic
  • CO2 extracted
  • 90-Day money-back guarantee

Nuleaf Naturals

Best Natural

Nuleaf Naturals

  • CO2 extraction
  • Organic
  • Vegan

Lazarus Natural

Best Selection

Lazarus Naturals

  • Third-party testing
  • Full-spectrum and THC free available
  • Variety of products offered

American Shaman Oil

Best Bioavailability

American Shaman

  • Organic hemp
  • Nanotechnology for better bioavailability
  • Discounts available for veterans and low-income individuals

Charlotte's Web

Best Variety

Charlotte’s web

  • THC free options available
  • Good option for beginners
  • CO2 extraction

How To Choose The Best CBD for Anxiety?

If you and your healthcare provider decide CBD may be a good option to treat your anxiety, you’ll want to choose a high-quality CBD oil to provide maximum benefits.

Type of CBD Extract

Before purchasing CBD products, it’s essential to know the types of CBD and the benefits associated with each. The three types of CBD extract include full-spectrum, broad-spectrum, and CBD isolate. The main differences between the three are the types of compounds they contain. Let’s dig a little deeper into each type to help you decide which is best for you.

Full-Spectrum CBD

Full-spectrum CBD oil contains phytonutrients and other naturally occurring cannabinoid compounds in the cannabis plant. Research[5] shows when naturally occurring plant compounds work together, health benefits may be maximized. This is known as the entourage effect[6].

Since full-spectrum CBD contains all of the plant’s naturally occurring compounds, it will have traces of THC. To be legal[7] on the federal level, products should have less than 0.3% THC. Even though it is not enough to get you high, traces of THC could show up on a drug test.

Broad-Spectrum CBD

Broad-spectrum CBD oil contains many naturally occurring compounds in the cannabis plant, including terpenes and other cannabinoids. Unlike full spectrum CBD, broad-spectrum CBD products do not contain traces of THC.  Since many compounds are present in this oil, it is believed to have similar health benefits to full-spectrum oils and may still create the  “entourage effect.”

CBD Isolate

CBD Isolate contains only CBD and does not contain any other naturally occurring compounds in the cannabis plant. Those who wish to avoid traces of THC altogether may consider CBD isolate. However, since CBD isolate is free of other naturally occurring compounds, it may not produce maximum results.

Extraction Method

One of the first things you’ll want to look at is the way the CBD oil is extracted. This can tell you a lot about the quality of the product. 

Some manufacturers choose to go a cheaper and easier route and use solvents like butane or ethanol to extract the oil. This can result in an unpleasant taste and possible unwanted side effects. 

Although it typically costs more, the gold standard in CBD extraction is using carbon dioxide (CO2). Carbon dioxide extraction involves using pressurized CO2 to pull out the beneficial compounds of the plant. This results in the highest quality, safest CBD oil.

Source of Hemp

When looking for a high-quality CBD product, you’ll want to choose a brand that creates its oils from organic hemp plants. Although hemp can be grown and cultivated anywhere, each country has different laws and standards. To ensure purity and quality, choose organic hemp grown in the United States. 

If hemp is grown in poor conditions, the plant may take in harmful toxins. When you choose a high-quality source of hemp grown in ideal conditions, the plant will thrive and absorb the nutrients it needs to provide you with maximum benefits. 

Third-Party Testing

Since CBD isn’t regulated by the FDA, some companies can get away with selling poor-quality CBD. The best way to have peace of mind knowing you’re selecting the highest-quality CBD products is by choosing a company that uses third-party testing by an independent lab. Most companies will also post third-party test results on their websites.

10 Best CBD Oil For Anxiety, Depression & Stress

With thousands of CBD brands and CBD oil products on the market, it can be difficult and time-consuming to gather information about each brand. We’ve put together a list of our 10 favorite CBD brands for anxiety disorders, depression, and stress. Check it out below!

CBDfx

cbdfx tincture

CBDfx is one of the most popular names in the industry. They produce organic, high-quality, infused oil tinctures to promote overall wellness.

  • Organic CBD
  • CBD+CBN
  • CO2 extracted
  • Infused CBD oil tinctures
  • Third-party tested
  • Does not offer regular full-spectrum hemp extract

CBDfx is an older company in the CBD industry and has been around since 2014. CBDfx is known for its high quality, pure CBD products, and excellent customer service. The wide range of CBD products sold by CBDfx are organic from seed to sale and are third-party tested for exceptional quality.

Their hemp oil is extracted from the cannabis plant by the “gold standard” CO2 method, and the oil tincture includes MCT oil to promote better bioavailability and absorption. 

CBDfx offers infused oils, including a broad spectrum sleep tincture which includes melatonin and CBN (the relaxation cannabinoid), and a full spectrum calming tincture that contains CBN and a blend of calming terpenes. Potencies offered by CBDfx range from 500mg-6000mg per bottle.

Spruce CBD Oil

Spruce-Max-Potency-CBD-Oil

Spruce CBD offers some of the highest potency, full-spectrum CBD oils on the market. This company is a great option if you’re looking for high-quality CBD with maximum potency to relieve anxiety symptoms.

  • Full-spectrum CBD from high-quality hemp strains
  • Third-party tested
  • High potency
  • Lab-grade strength
  • Ethanol extraction method
  • A little more expensive than most
  • No flavors available

Spruce CBD has been around since 2018 and is considered one of the best options on the market to treat anxiety symptoms. They’re a family-run business that uses a unique, high-quality strain of hemp that dates back to 1812. 

All products are grown organically in Kentucky and North Carolina and are extracted with alcohol. Spruce’s CBD oils are pesticide-free and made with all-natural ingredients. They offer an extra-strength formula that contains 80 mg of CBD per dropper or 2,400 mg of CBD per bottle.

Though their oils are unflavored, they frequently have a limited edition seasonal flavor available.

Joy Organics

Joy organics

Joy Organics offers high-quality, broad-spectrum CBD oil that is completely free of THC and USDA-Certified Organic.

  • Organic, non-GMO CBD
  • THC-free available
  • High-quality hemp
  • CO2 extraction
  • Third-party tested
  • A little bit more expensive than most

Joy Organics is a family-run business that was founded in 2018. They are known for their THC-free CBD products. The company sources its CBD products from organically grown hemp that is extracted with CO2.

Recently, Joy Organics has added full-spectrum CBD products with traces of THC to their lineup. All third-party test results are published on their website to ensure purity and transparency with customers.

The company’s CBD potencies range from 250-2250 mg per bottle. Flavors offered include tropical sunrise, fresh lime, and tranquil mint.

Royal CBD

Royal CBD Oil

Royal CBD offers some of the most potent full-spectrum CBD products on the market. Their high-quality CBD oils come in a variety of flavors that’s sure to satisfy your tastebuds.

  • Third-party tested
  • Wide variety of flavors
  • Several concentrations offered
  • Full-spectrum CBD
  • C02 Extraction method
  • Made with 100% organic ingredients
  • Limited flavors offered
  • Expensive

Royal CBD puts customer satisfaction as a top priority. Their high-quality CBD oils are made with 100% organic ingredients, extracted with cO2, and come with third-party lab results for transparency. 

They offer some of the highest potency CBD oils on the market. Their most potent full-spectrum CBD oil provides 2500 mg of CBD per bottle. Due to the high potency, this option is only available with natural flavors. However, the company offers lower potency options in various flavors, including mint, berry, natural, and vanilla.

Products come with a higher price tag, but the products offered are some of the highest quality on the market

CBDPure

CBDPure-Oil

If you’re looking for a high-quality CBD oil that is budget-friendly, CBD Pure oils are a great option.

  • Affordable
  • Third-party tested
  • Certified organic
  • CO2 extracted
  • 90-Day money-back guarantee
  • No flavors
  • Limited product selection

CBD Pure was founded in 2016 and has been selling high-quality, organic CBD oil ever since. Their CBD products are USDA-certified organic and are free of additives and artificial flavorings. 

Their CBD oils are combined with organic hemp seed oil containing 300mg, 600mg, or 1000mg of full-spectrum CBD oil. If you’re unsatisfied with a product offered by CBD Pure, you can return it within 90 days and get your money back. 

CBDIstillery

CBDistillery

CBDIstillery offers high-quality, affordable CBD oils with very high potency options available.

  • High potency available
  • Third-party tested
  • Competitive pricing
  • U.S. Hemp Authority certified
  • CO2 extracted
  • Limited flavors available

CBDistillery was founded in 2016 by a group of Colorado natives. Today, the company leads the industry, and their high potency oils are in serious demand. All of their oils come from organic, non-GMO hemp plants that have been third-party tested for quality and safety.

Their full-spectrum oils come in 30ml bottles with potencies ranging from 500-5000 mg of CBD.

If you’re looking to avoid negligible amounts of THC, CBD Distillery also offers 0% THC oils.

NuLeaf Naturals

Nuleaf Naturals

NuLeaf Naturals offers full-spectrum, hemp-seed infused oils with some of the highest concentrations available on the market.

  • Third-party tested
  • CO2 extraction
  • Organic
  • Vegan
  • Full-spectrum CBD
  • Lack of flavor options

NuLeaf Naturals has been around since 2014 and has been a key player in the CBD market for years. They use 100% non-GMO hemp plants for their extracts. Additionally, NuLeaf Naturals uses advanced supercritical CO2 extraction to ensure a pure, clean end product is achieved. 

They also offer some of the highest potency CBD products on the market, with concentrations ranging from 300 mg-6000mg per 15 mL bottle.

Lazarus Naturals

Lazarus Natural

Lazarus naturals offer high-quality CBD and are one of the most affordable brands on the market.

  • Affordable prices
  • Third-party testing
  • Full-spectrum and THC free available
  • Variety of products offered
  • Offers assistance program for special populations
  • Organic hemp
  • Limited range of certified organic products

Lazarus Naturals believes in producing high-quality CBD products that are easily accessible and affordable for the general population. They take pride in the quality of their products by using a “farm to door” approach. Lazarus Naturals also offers up to 60% off for veterans, those on long-term disability, and other special populations.

The company offers a plethora of ethanol extracted full spectrum CBD and CBD isolate without THC. Potencies range from 750-6000 mg of CBD per bottle and come in a variety of flavors.

American Shaman

American Shaman Oil

American Shaman employs nanotechnology for 9x better bioavailability, making their product absorption faster and more efficient than other brands on the market.

  • Wide variety of products
  • Organic hemp
  • Nanotechnology for better bioavailability
  • Discounts available for veterans and low-income individuals
  • Third-party tested
  • CO2 extraction
  • More expensive than other brands

American Shaman is one of the leaders in the CBD market today, for a good reason!

They employ nanotechnology to increase product bioavailability and promote faster, more efficient absorption in our bodies. All CBD is extracted using CO2 and is free from harmful substances.

All products go through rigorous testing to ensure quality and potency. They offer an impressive selection of CBD oils ranging in flavor and potency and offer THC-free options. Potencies range from 150-900 mg per 30 fl oz bottle.

American Shaman also has the Compassionate Care program established, which provides discounts for those in need.

Charlotte’s Web

Charlotte's Web

If you’re new to CBD, Charlotte’s Web may be a good option.

  • Made from U.S grown hemp plant
  • Affordable
  • THC-free options are available
  • A good option for beginners
  • CO2 extraction
  • The company has two class-action lawsuits
  • The company has received an FDA warning before
  • Not currently certified organic

Charlotte’s Web was founded in 2014 by two brothers who developed a high-quality hemp strain to help a five-year-old girl with epilepsy reduce seizures.

Their website is easy to navigate and provides suggestions on where to start for those new to CBD products. They use CO2 extraction and have low-dose options available.

How Can CBD Manage Anxiety & Depression?

Doctors and researchers are still trying to figure out the exact mechanism behind CBD to relieve symptoms associated with anxiety disorders and depression. This is mainly because, until recently, federal regulations made it difficult to conduct research and clinical trials using CBD.

Many believe that CBD oil interacts with the serotonin in our brain, similar to prescription medications like selective serotonin reuptake inhibitors (SSRIs), and work to relieve anxiety-related symptoms, act as a mood enhancer, and fight depression.

Some research[8] also suggests that it may help with anxiety by affecting serotonin levels in the brain. Of note, this study also concluded that we should do more research to determine the precise mechanism.

One small[8] human study found that CBD reduced anxiety in participants with social anxiety before a public-speaking event. 

Risk & Potential Side Effects

Generally, CBD is considered safe. However, certain people may have adverse reactions when taking CBD.  

According to studies[9], the most common side effects associated with CBD use are:

  • Fatigue
  • Diarrhea
  • Changes in appetite
  • Weight changes

Additionally, CBD is known to interact with certain medications[10], especially those with grapefruit warnings. This is because CBD, similar to grapefruit, may interfere with enzymes like cytochromes P450, which are needed for drug metabolism.

CBD Oil Dosage 

Since research remains limited, there are no set CBD dosages in mg for anxiety relief at this time. 

However, one study[10] in several male subjects found that an oral dose of 300 mg of CBD given approximately 90 minutes before a speech was enough to reduce the speakers’ anxiety.

Like many medications, it’s essential to start with a very low dose and gradually increase as needed until symptom relief is achieved. 

It’s important to always speak with your doctor or qualified healthcare practitioner before using CBD oil to discuss how much CBD oil you should take. 

The Bottom Line 

Anxiety is a common disorder that can destroy your social life if left untreated. It’s important to discuss treatment options, including CBD oil, with your healthcare provider to determine your best options.

While more research should be done, CBD oil appears to potentially be a safe, natural option to treat anxiety and anxiety-related disorders. If you decide to try CBD oil for anxiety or depression, be sure to select a high-quality product and always do your research before buying. 

Frequently Asked Questions

Does CBD help anxiety symptoms?

Although additional research is needed, some studies (as mentioned above) have reported symptom relief with CBD treatment. There is also anecdotal evidence that CBD may help with symptoms of anxiety. It’s always important to speak with a qualified healthcare provider before use. – 350

Will CBD make me high?

No, CBD is a non-psychoactive compound and will not make you high. However, full-spectrum CBD extract may contain traces of THC, which could result in a failed drug test. If you prefer not to have THC in your body, consider broad-spectrum CBD extract.

What form of CBD is most effective for anxiety and depression?

Full-spectrum CBD oil is often considered the best because it contains all of the compounds that naturally occur in the hemp plant. This is because you may benefit from the Entourage Effect, which increases benefits when the compounds can synergistically work together for symptom relief.

Medically reviewed by:

Lindsey DeSoto is a Registered Dietitian Nutritionist based out of Coastal Mississippi. She earned her BSc in Nutrition Sciences from the University of Alabama. Lindsey has a passion for helping others live their healthiest life by translating the latest evidence-based research into easy-to-digest, approachable content.

Medically reviewed by: